episteme

STEM SCIENCE

ROHTO Pharmaceutical Regenerative
Medicine Research Center takes the challenge
of the anti-glycation technology.

From the advanced research of
ROHTO
Pharmaceutical,
Innovative elastic skin science.

Never compromise to accomplish ideal aging care
we have kept challenging for innovation since 2015
when we launched the Steme science series.
Fusion of the pharmaceutical company's cell culture
technology and skin mechanism research.
For elastic and vibrant skin, as though it were newly awakening from the base.

Features of the series

Approaching the root of elasticity,
Awakening vibrant elasticity

Stem S Complex compound

Stem Energy Complex compound

Adoption of a unique high-
penetration formulation
Soundly delivering the components you want to the parts
where they are needed.

Deep Target Delivery formulation

Aging skincare: Care for moisture and elasticity corresponding to age
Source of elasticity: Keratinocyte
Source of beauty: Stratum corneum
Stem S Complex: Caprooyl Tetrapeptide-3, Copper tripeptide-1, Collagen (moisturizing ingredient)
Stem Energy Complex: Prune fragment, Aloevera leaf extract (moisturizing ingredient)
Highest peak: In the episteme brand
High-penetration formulation: To the stratum corneum

Stem Energy Complex compound: Blend of Stem Science Lotion a, Stem Science Emulsion a, and Stem Science Lift Cream a

STEM SCIENCE OIL

Beauty serum oil

Works on skin firmness from skin’s foundation. A prep serum oil with PQQ※1.

Volume: 26mL
Price: 11,000 yen

PQQ*1 blended in a 100% oil base by an encapsulation technology. The prep serum oil is to be used before applying lotion to soften and regulate skin prone to roughness.

<Key ingredients>

PQQ※1

※1:Disodium pyrroloquinolinedione tricarboxylate (regulates and moisturizes skin)

STEM SCIENCE lotion

Elastin/moisturizing toner

Instantly infiltrates to moisturize skin and add elasticity.

Volume: 150ml
Price: 15,000 yen

Containing the “Stem Energy Complex”, the thick toner can fast infiltrate into skin to render it plump and elastic.

<Key ingredients>

Stem Energy Complex※1, Stem S Complex※2, Vitalize Complex※3, AG Deep Clear Complex※4: Supplement of moisture and elasticity for skin.

※1:Hydrolyzed prunus domestica, and aloe vera extract (moisturizing ingredient)
※2:Caprooyl tetrapeptide3, copper tripeptide-1, and collagen (moisturizing ingredient)
※3:Glycine soja (soybean) germ extract, and oligopeptides-24 (moisturizing ingredient)
※4:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE emulsion

Elasticity/moisturizing emulsion

For a tender and delicate skin.

Volume: 45g
Price: 15,000 yen

Containing the “Stem Energy Complex”, the creamy emulsion has a soft texture and improves skin in elasticity, and smoothness.

<Key ingredients>

Stem Energy Complex※1、Stem S Complex※2、Vitalize Complex※3
AG Deep Clear Complex※4: Supplement of moisture and elasticity for skin.

※1:Hydrolyzed prunus domestica, and aloe vera extract (moisturizing ingredient)
※2:Caprooyl tetrapeptide3, copper tripeptide-1, and collagen (moisturizing ingredient)
※3:Glycine soja (soybean) germ extract, and oligopeptides-24 (moisturizing ingredient)
※4:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE lift cream

Elasticity/moisturizing cream

A top thick cream that effectively firms skin.

Volume: 45g
Price: 33,000 yen

Containing the high-concentration “Stem Energy Complex”, the thick cream closely adheres to skin to make it the ideal delicate skin.

<Key ingredients>

Stem Energy Complex※1、Stem S Complex※2、Vitalize Complex※3、 AG Deep Clear Complex※4: Supplement of moisture and elasticity for skin.

※1:Hydrolyzed prunus domestica, and aloe vera extract (moisturizing ingredient)
※2:Caprooyl tetrapeptide3, copper tripeptide-1, and collagen (moisturizing ingredient)
※3:Glycine soja (soybean) germ extract, and oligopeptides-24 (moisturizing ingredient)
※4:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE RX cream

cream

Bringing you well-defined, contoured skin.
A rich cream offering full moisture and firmness.

Volume: 45g
Price: 50,000 yen

This is an epitome※1 of a cream born out of ROHTO Pharmaceutical’s frontier research.
The rich cream leaves your skin fully moist and firm.
Bringing you well-defined, contoured skin.

※1:Within episteme​

<Key ingredients>

Stem Remodel Complex※2、Stem CM※3、Stem S Complex※4、 Vitalize Complex※5、AG Deep Clear Complex※6

※2:Glycogen, tetrapeptide-5 (moisturizing ingredient)
※3:Hydrolyzed stem cell conditioned media (moisturizing ingredient)
※4:Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (moisturizing ingredient)
※5:Glycine Soja (Soybean) Germ Extract, oligopeptides-24 (moisturizing ingredient)
※6:Prunus mume fruit extract, edelweiss extract (moisturizing ingredient)

STEM SCIENCE RX shot

The top anti-aging essence

A booster of skin elasticity.

Volume: 8mL×4 bottles
Price: 38,000 yen

From the advanced research of ROHTO Pharmaceutical, the serum contains the world’s first※11 Stem CM, which increases skin elasticity.
The top※2serum adds nourishment and elasticity to skin to bring you skin texture that you have never had.

※1:ROHTO is the world‘s first to add the Stem CM to skincare products
※2:In the episteme products

<Key ingredients>

Stem CM※3, Stem S Complex※4, Vitalize Complex※5, AG Deep Clear Complex※6: A selected and repeatedly researched ingredient that renders skin moisturized, elastic and bright.

※3:Hydrolyzed stem cell naturalizing culture medium (moisturizing ingredient)
※4:Caprooyl tetrapeptide-3, copper tripeptide-1, and collagen (moisturizing ingredient)
※5:Glycine soja (soybean) germ extract, and oligopeptides-24 (moisturizing ingredient)
※6:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)