episteme

episteme
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STEM SCIENCE

ROHTO Pharmaceutical Regenerative
Medicine Research Center takes the challenge
of the anti-glycation technology.

From the advanced research of
ROHTO
Pharmaceutical,
Innovative elastic skin science.

Never compromise to accomplish ideal aging care
we have kept challenging for innovation since 2015
when we launched the Steme science series.
Fusion of the pharmaceutical company's cell culture
technology and skin mechanism research.
For elastic and vibrant skin, as though it were newly awakening from the base.

Features of the series

Approaching the root of elasticity,
Awakening vibrant elasticity

Stem S Complex compound

Stem Full Complex compound

Stem Energy Complex compound

Adoption of a unique high-
penetration formulation Soundly delivering the components you want to the parts
where they are needed.

Deep Target Delivery formulation

Aging skincare: Care for moisture and elasticity corresponding to age
Source of elasticity: Keratinocyte
Source of beauty: Stratum corneum
Stem S Complex: Caprooyl Tetrapeptide-3, Copper tripeptide-1, Collagen (moisturizing ingredient)
Stem Full Complex: Averrhoa carambola leaf extract, Rooibos extract, Rosa canina extract (moisturizing ingredient)
Stem Energy Complex: Prune fragment, Aloevera leaf extract (moisturizing ingredient)
Highest peak: In the episteme brand
High-penetration formulation: To the stratum corneum

Stem S Complex, Stem Energy Complex, Stem Full Complex : Formulation in Stem Science Lotion b, Stem Science Emulsion b, and Stem Science Lift Cream b.

STEM SCIENCE cleansing a

Cleansing cream

With every wash, experience heightened freshness※1 for your adult skin.
Cleansing that leads to firmer skin.

110g/8,000 yen

Conditions the skin environment to achieve skin moisturized even after removing makeup. Contains Deep Clear Complex EX-C※2.

＜Key ingredients＞

Deep Clear Complex EX-C※2
Stem S Complex※3

※1: Clear skin surface free of dirt.
※2: (Moisturizing Ingredients) Rosa roxburghii fruit extract, vaccinium myrtillus, bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate, Limnanthes alba (meadowfoam) seed oil, rosa canina fruit oil, argania spinosa kernel oil, (Washing Ingredient) sodium cocoyl glycinate
※3: Prunus mume fruit extract, leontopodium alpinum flower/leaf extract (Moisturizing Ingredients)

STEM SCIENCE wash a

Face wash

With every wash, experience heightened freshness※1 for your adult skin.
Cleansing that leads to firmer skin.

100g/7,000 yen

Conditions the skin environment to achieve skin moisturized after washing. Contains Deep Clear Complex EX-W※2.

＜Key ingredients＞

Deep Clear Complex EX-W※2
Stem S Complex※3

※1: Clear skin surface free of dirt
※2:(Moisturizing Ingredients) Rosa roxburghii fruit extract, vaccinium myrtillus, bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate, Limnanthes alba (meadowfoam) seed oil, rosa canina fruit oil, argania spinosa kernel oil, (Washing Ingredient) sodium cocoyl glycinate
※3: Prunus mume fruit extract, leontopodium alpinum flower/leaf extract (Moisturizing Ingredients)

STEM SCIENCE OIL

Oil serum

Works on skin firmness from skin’s foundation. A prep serum oil with PQQ※1.

Volume: 26mL
Price: 11,000 yen

PQQ*1 blended in a 100% oil base by an encapsulation technology. The prep serum oil is to be used before applying lotion to soften and regulate skin prone to roughness.

＜Key ingredients＞

PQQ※1

※1:Disodium pyrroloquinolinedione tricarboxylate (regulates and moisturizes skin)

STEM SCIENCE lotion

Aging care lotion

Omnidirectional*1 evolution.
Dissolves into the skin for a plump and elastic feel

※1:Firmness, gloss, and moisture

Volume: 150ml
Price: 15,000 yen

“Stem Full Complex” formulation. Although a little consistency, it dissolves into the skin and permeates down to the horny layer for skin with a fluffy and firm feel.

＜Key ingredients＞

Stem Full Complex※2
Stem Energy Complex※3
Stem S Complex※4
Vitalize Complex※5
AG Deep Clear Complex※6

※2:Averrhoa carambola leaf extract, Rooibos extract, Rosa canina extract (moisturizing ingredient)
※3:Prune fragments, aloe leaf extract (moisturizing ingredient)
※4:Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (moisturizing ingredient)
※5:Soybean germ extract, oligopeptides-24 (moisturizing ingredient)
※6:Ume fruit extract, Leontopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE emulsion

Aging care emulsion

Soft and soothing, for perky firmness. *Recipient of the Best Cosmetics Award

45g/15,000 yen
Refill 45g/14,000 yen

“Stem Full Complex*1” formulation. Smooth creamy emulsion. For moisture and firm, springy and supple skin.

＜Key ingredients＞

Stem Full Complex※1
Stem Energy Complex※2
Stem S Complex※3
Vitalize Complex※4
AG Deep Clear Complex※5

※1:Averrhoa carambola leaf extract, Rooibos extract, Rosa canina extract (moisturizing ingredient)
※2:Hydrolyzed prunus domestica, aloe vera extract (moisturizing ingredient)
※3:Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (moisturizing ingredient)
※4:Glycine soja (soybean) germ extract, oligopeptides-24 (moisturizing ingredient)
※5:Prunus mume fruit extract, Leontopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE lift cream

Aging care cream

Dense richness for a springy and blissfully firm feel.

45g/33,000 yen
Refill 45g/32,000 yen

“Stem Full Complex” Ultimate density*1 formulation. This dense cream endowed with smoothness and richness adheres to the skin to give a firm, springy feel.

※1:Densest formulation within the brand

＜Key ingredients＞

Stem Full Complex※2
Stem Energy Complex※3
Stem S Complex※4
Vitalize Complex※5
AG Deep Clear Complex※6

※2:Averrhoa carambola leaf extract, Rooibos extract, Rosa canina extract (moisturizing ingredient)
※3:Prune fragments, aloe leaf extract (moisturizing ingredient)
※4:Glycine soja (soybean) germ extract, oligopeptides-24 (moisturizing ingredient)
※5:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)
※6:Prunus mume fruit extract, Leontopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE eye

eye cream

Challenging age shadow※1 in eyelids. Next-generation eye cream for amazing firmness.

18g/18,000 yen

Episteme’s best ever next-generation eye cream made with “Deep Liftical Complex ※2” formulation for a deeper approach to eye troubles. For vibrant and firm eyes.

＜Key ingredients＞

Deep Liftical Complex※2
Stem Full Complex※3
Stem Energy Complex※4
Stem S Complex※5
Vitalize Complex※6
AG Deep Clear Complex※7

※1:Skin dryness and reduced firmness that appear with aging.
※2: Tea leaf extract, soybean seed extract (moisturizing ingredient)
※3:Averrhoa carambola leaf extract, Rooibos extract, Rosa canina extract (moisturizing ingredient)
※4:Prune fragments, aloe leaf extract (moisturizing ingredient)
※5:Glycine soja (soybean) germ extract, oligopeptides-24 (moisturizing ingredient)
※6:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)
※7:Prunus mume fruit extract, Leontopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE RX cream

Rich anti-aging cream

Bringing you well-defined, contoured skin.
A rich cream offering full moisture and firmness.

Volume: 45g
Price: 50,000 yen

This is an epitome※1 of a cream born out of ROHTO Pharmaceutical’s frontier research.
The rich cream leaves your skin fully moist and firm.
Bringing you well-defined, contoured skin.

※1:Within episteme​

＜Key ingredients＞

Stem Remodel Complex※2
Stem CM※3
Stem S Complex※4
Vitalize Complex※5
AG Deep Clear Complex※6

※2:Glycogen, tetrapeptide-5 (moisturizing ingredient)
※3:Hydrolyzed stem cell conditioned media (moisturizing ingredient)
※4:Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (moisturizing ingredient)
※5:Glycine Soja (Soybean) Germ Extract, oligopeptides-24 (moisturizing ingredient)
※6:Prunus mume fruit extract, edelweiss extract (moisturizing ingredient)

STEM SCIENCE RX shot

Concentrate anti-aging essence

A booster of skin elasticity.

Volume: 8mL×4 bottles
Price: 38,000 yen

From the advanced research of ROHTO Pharmaceutical, the serum contains the world’s first※11 Stem CM, which increases skin elasticity.
The top※2serum adds nourishment and elasticity to skin to bring you skin texture that you have never had.

※1:ROHTO is the world‘s first to add the Stem CM to skincare products
※2:In the episteme products

＜Key ingredients＞

Stem CM※3
Stem S Complex※4
Vitalize Complex※5
AG Deep Clear Complex※6
: A selected and repeatedly researched ingredient that renders skin moisturized, elastic and bright.

※3:Hydrolyzed stem cell naturalizing culture medium (moisturizing ingredient)
※4:Caprooyl tetrapeptide-3, copper tripeptide-1, and collagen (moisturizing ingredient)
※5:Glycine soja (soybean) germ extract, and oligopeptides-24 (moisturizing ingredient)
※6:Prunus mume fruit extract, and leotopodium alpinum extract (moisturizing ingredient)

STEM SCIENCE CC

CC cream

Skincare while applying makeup. CC cream for elastic skin.

32g/8,000 yen

Finally, heralding the age of elastic skin※1 care through makeup.
This CC cream adheres to bare skin with a texture that feels just like beauty essence.
Rub in as though lifting the cheeks for firm skin elasticity.
This one product can serve as an elastic beauty essence, UV block, base and foundation.

SPF31, PA+++

※1: Moist and elastic state

STEM SCIENCE CC POWDER

Face powder

A single layer is enough to remove dullness※1. Powder for glossy skin.

13g/7,000 yen

This CC powder transforms makeup time to skincare.
This one product imparts a skincare effect, foundation effect, highlight effect, and UV cut effect※2.
Covering dullness caused by aging, etc., it helps to create transparent, glossy skin.

＜Key ingredients＞

Stem S Complex※3
Vitalize Complex※4
CC pearl, tone change powder EX

※1: Based on the making-up effect
※2: UV cut effect: SPF27, PA+++
※3: Caprooyl tetrapeptide-3, copper tripeptide-1, collagen (moisturizing ingredient)
※4: Glycine soja (soybean) germ extract, oligopeptides-24 (moisturizing ingredient)